Study on the distribution of vitamin D receptor gene start codon polymorphism in the Achangs and Hans / 中华医学遗传学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To detect the difference between the Chinese Achang and Han ethnic groups in Yunnan province in the distribution of vitamin D receptor (VDR) gene start codon polymorphism.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism, gene sequencing and genetic analysis methods were used. A restriction fragment length polymorphism in the start codon of VDR (Fok I) gene was tested in the Achangs (n=68) and the Hans (n=92).</p><p><b>RESULTS</b>The frequencies of FF, Ff and ff genotypes were found to be 18%, 35% and 47% in the Achangs, and 22%, 52% and 26% in the Hans, respectively. A significant difference was seen in the frequency distribution of VDR genotype between the Achangs and the Hans(Chi2=7.716, P=0.021).</p><p><b>CONCLUSION</b>The Achang and Han ethnic groups differ in the frequency distribution of VDR gene start codon polymorphism.</p>