Study of a novel dissoluble adhesive and its application in tissue engineering / 生物医学工程学杂志

ABSTRACT

In order to prepare three-dimensional scaffolds with "ideal pore-structure" for tissue engineering, a novel water dissoluble adhesive was developed, and the property of adhesive as well as influence of experimental condition on bonded porogen assembly was investigated. Experimental results showed that it was possible to fabricate large dimensional porogen assembly with homogenous and controllable bonding extent by this adhesive, and a large dimensional (45 mm in diameter, 55mm in thickness) biodegradable poly(D,L-lactic acid)(PDLLA) scaffold resulting from bonded porogen was formed. The scaffolds with high porosity as well as with controllable and homogeneous inner-structure can be easily formed. In addition, pore size of scaffolds as well as diameter of openings can be controlled by adjusting the porogen size and bonding degree in bonded porogen assembly.