Expression of RhoC protein in human primary hepatocellular carcinoma and its clinical significance / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 394-396, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-332136
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expression of RhoC protein in human primary hepatocellular carcinoma (HCC) and pericancerous liver (PCL) tissues and its relation to HCC prognosis.</p><p><b>METHODS</b>Immunohistochemical method was used to detect the expression of RhoC protein in HCC, PCL of 43 patients. Thirty-six patients were followed up after they received radical resection.</p><p><b>RESULT</b>The expression of RhoC protein in HCC was significantly higher than that in PCL. Rhoc expression was increased in cases with poor differentiation, portal vascular invasion, unintact envelope and multiple masses. The survival analysis showed that HCC with lower RhoC protein expression had better clinical outcomes.</p><p><b>CONCLUSION</b>RhoC protein expression is correlated with infiltration and metastasis in HCC. RhoC protein can be used as a prognostic indicator for HCC.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Prognóstico
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Carcinoma Hepatocelular
/
Proteínas rho de Ligação ao GTP
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Proteína de Ligação a GTP rhoC
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Genética
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Neoplasias Hepáticas
/
Metabolismo
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Invasividade Neoplásica
/
Metástase Neoplásica
Tipo de estudo:
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2006
Tipo de documento:
Artigo