Association of peripheral blood hypoxia-inducible factor-1α with metastasis of colorectal cancer / 南方医科大学学报
Journal of Southern Medical University
; (12): 705-706, 2011.
Article
em Zh
| WPRIM
| ID: wpr-332569
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the relationship between hypoxia-inducible factor-1α (HIF-1α) mRNA levels in the peripheral blood and the metastasis of colorectal cancer.</p><p><b>METHODS</b>HIF-1α mRNA in the peripheral blood was detected by RT-PCR in 40 patients with colorectal cancer and 20 healthy subjects.</p><p><b>RESULTS</b>Seventeen patients with colorectal cancer showed positivity for HIF-1α mRNA, showing a significantly higher positivity rate (42.5%) than the healthy subjects (P<0.05). The expression of HIF-1α mRNA is closely related to the staging of colorectal cancer (CRC).</p><p><b>CONCLUSION</b>HIF-1α mRNA may serve as a potential marker in the detection of metastasis of colorectal cancer.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Sangue
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RNA Mensageiro
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Neoplasias Colorretais
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Adenocarcinoma
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Estudos de Casos e Controles
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Subunidade alfa do Fator 1 Induzível por Hipóxia
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Genética
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Invasividade Neoplásica
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Metástase Neoplásica
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Southern Medical University
Ano de publicação:
2011
Tipo de documento:
Article