Current understanding of iron overload hazard in patients with myelodysplastic syndrome / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 484-488, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-332752
Biblioteca responsável:
WPRO
ABSTRACT
Patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop into transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Thereby our current understanding of the effects of transfusion dependency and iron overload in MDS are discussed. Particular emphasis should be placed on further characterizing the role of redox-active forms of labile iron and oxidative stress in iron overload, decreased life expectancy and increased risk of leukemic transformation in MDS patients with iron overload.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Síndromes Mielodisplásicas
/
Estresse Oxidativo
/
Sobrecarga de Ferro
/
Ferro
/
Metabolismo
Limite:
Humanos
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2013
Tipo de documento:
Artigo