Progress in calcium regulation in myocardial and vascular ischemia-reperfusion injury / 生理学报
Acta Physiologica Sinica
; (6): 321-326, 2012.
Article
em Zh
| WPRIM
| ID: wpr-333195
Biblioteca responsável:
WPRO
ABSTRACT
Ischemia-reperfusion injury (IRI) has been recognized as a serious problem for therapy of cardiovascular diseases. Calcium regulation appears to be an important issue in the study of IRI. This article reviews calcium regulation in myocardial and vascular IRI, including the calcium overload and calcium sensitivity in IRI. This review is focused on the key players in Ca(2+) handling in IRI, including membrane damage resulting in increase in Ca(2+) influx, reverse-mode of Na(+)-Ca(2+) exchangers leading to increased Ca(2+) entry, the decreased activity of sarcoplasmic reticulum (SR) Ca(2+)-ATPase causing SR Ca(2+) uptake dysfunction, and increased activity of Rho kinase. These key players in Ca(2+) homeostasis will provide promising strategies and potential targets for therapy of cardiovascular IRI.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Retículo Sarcoplasmático
/
Traumatismo por Reperfusão Miocárdica
/
Cálcio
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Trocador de Sódio e Cálcio
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ATPases Transportadoras de Cálcio do Retículo Sarcoplasmático
/
Coração
/
Homeostase
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Metabolismo
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Miocárdio
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Ano de publicação:
2012
Tipo de documento:
Article