Effects of human urotensin II on pia mater microcirculation in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 46-49, 2004.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-333720
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the effects of human urotensin II (hUII) on in vivo pia mater microcirculation in rats.</p><p><b>METHODS</b>Adult SD rats were randomly assigned to the following groups control, sodium chloride injection (NS), UII(10(-6) mol/L), noradrenaline (NA, 10(-6) mol/L), and UII (10(-6) mol/L) + NA (10(-6) mol/L) groups. For recording of microcirculation images in pia mater, skull windows were performed and mounted on the stage of an intravital microscope equipped with a TV camera. Video images of microcirculation were stored by a video cassette recorder. Temporal changes in internal diameter and microcirculatory velocity of microvessels were measured by computer using the Image Pro software. The blood flow in cerebral tissues were measured with PIMII laser Doppler perfusion Imager (Lisca, Sweden).</p><p><b>RESULTS</b>The internal diameters of arterioles and venules in control group were (35.4 +/- 3.6) microm and (40.6 +/- 8.5) microm, respectively. In UII group, the arterioles and venules contracted immediately after treated with UII and up to the peak at 1 min, the internal diameters of arterioles and venules were (25.6 +/- 3.4) microm and (23.4 +/- 3.3) microm, respectively (P < 0.05). Both microcirculatory velocity in arterioles and venules had no significant changes in UII group (P > 0.05). The blood flow in meninges increased 1 min after treated with UII and up to high peak at 5 min (3.5 +/- 0.4 perfusion unit vs. control 2.3 +/- 0.6, P < 0.05).</p><p><b>CONCLUSION</b>hUII can contract microvessels in pia mater of rats and increase microcirculatory blood perfusion to cerebral tissue involved.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Urotensinas
/
Circulação Cerebrovascular
/
Ratos Sprague-Dawley
/
Microcirculação
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2004
Tipo de documento:
Artigo