Effect of bradykinin on the sodium channel current in dorsal root ganglion neuron / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigate the effects of bradykinin on voltage-dependent sodium channel currents in rat dorsal root ganglion neurons (DRG).</p><p><b>METHODS</b>Whole-cell patch clamp technique was used to determine sodium channel current.</p><p><b>RESULTS</b>Bradykinin at 0.01 - 10.0 micromol/L dose dependently increased the frequency of repetitive firing of DRG. Bradykinin at 0.01 - 10.0 micromol/L dose dependently enhanced the TTX-R sodium current, and had no effect on TTX-S sodium current.</p><p><b>CONCLUSION</b>Mechanism underlying the inflammation induced by bradykinin is related to the TTX-R sodium channel.</p>