Tyrosine kinase mutation and acute myeloid leukemia with T (8; 21) / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 866-869, 2009.
Article
em Zh
| WPRIM
| ID: wpr-334007
Biblioteca responsável:
WPRO
ABSTRACT
This study was aimed to investigate the status of c-KIT, Fms-like tyrosine kinase 3 (FLT3) and Janus kinase 2 (JAK2) mutations in acute myeloid leukemia (AML) patients with t (8; 21) and to analyze their relation to clinical feature and prognosis. PCR, AS-PCR, restriction and sequencing methods were used respectively to detect the FLT3, JAK 2 and c-KIT mutations in 8 cases of de novo AML with t (8; 21) and 6 cases of relapsed AML with t (8; 21). The results showed that the c-KIT mutation was found in 2 cases out of 14 AML patients with t (8; 21) (14.3%), among them 1 case had c-KIT D816V mutation, the other had c-KIT D816Y mutation. The FLT3-ITD mutation was detect in 1 out of 14 patients (7.1%), but JAK2 mutation could not be detected in all 14 cases. In conclusion, tyrosine kinase mutation relates to AML with t (8; 21), patients with tyrosine kinase mutation may have higher relapse, extramedullary infiltration and poor prognosis. The screening c-KIT, FLT3 mutations may play an important role in evaluating prognosis and guiding treatment of t (8; 21) AML.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Leucemia Mieloide Aguda
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Proteínas Proto-Oncogênicas c-kit
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Sequências de Repetição em Tandem
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Tirosina Quinase 3 Semelhante a fms
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Janus Quinase 2
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Genética
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Mutação
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2009
Tipo de documento:
Article