The value of gamma-glutamyltransferase in the diagnosis of chronic hepatitis B / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 120-122, 2002.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-334294
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the change of serum gamma-glutamyltransferase (GGT) and its diagnosis value in chronic hepatitis B (CHB) patients with different degrees of liver damage.</p><p><b>METHODS</b>Alanine-aminotransferase (ALT), aspartate-aminotransferase (AST) and GGT were measured in 221 CHB patients. Liver biopsy was conducted simultaneously to determine the inflammation grade and fibrosis stage of the liver tissues.</p><p><b>RESULTS</b>The rate of normal GGT in pathologically diagnosed mild and severe CHB patients was 90.4% and 12.3%, respectively (P<0.01). Increased level of GGT was parallel to the degree of liver pathological change (P<0.01). In active CHB patients, GGT rose with the ALT increase with a positive linear correlation between them (r=0.464, P<0.001). In pathologically diagnosed mild CHB patients, GGT had a tendency of rapidly declining to normal levels with ALT. In moderate CHB patients, GGT fluctuated at a relatively high level, and in severe CHB patients GGT exhibited a deviation from GGT.</p><p><b>CONCLUSIONS</b>GGT is conducive to improve the coincident rate between the clinical and pathological diagnosis of CHB.</p>
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Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.3 Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
/
Hepatite
/
Doenças do Sistema Digestório
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Aspartato Aminotransferases
/
Fatores de Tempo
/
Sangue
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Índice de Gravidade de Doença
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Fibrose
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Valor Preditivo dos Testes
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Hepatite B Crônica
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Diagnóstico
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Alanina Transaminase
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2002
Tipo de documento:
Artigo