Application of mycophenolate mofetil in hepatitis C patients after kidney transplantation / 南方医科大学学报
Journal of Southern Medical University
; (12): 1215-1221, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-334955
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To discuss adequate application of mycophenolate mofetil (MMF) in hepatitis C patients after kidney transplantation.</p><p><b>METHOD</b>A one-year follow-up study was conducted in 49 patients with hepatitis C but normal liver function before kidney transplantation, who were given postoperatively immunosuppressants of predisone, MMF and CsA/FK506. Patients with abnormal liver function after kidney transplantation who continued MMF therapy at routine dose and those with reduced or suspended MMF therapy all received intravenous therapy for liver protection, and the duration of therapies was recorded.</p><p><b>RESULTS</b>Nineteen patients presented with abnormal liver function after operation, and the duration of abnormal liver function till recovery was 32.82-/+4.13 days in the patients with unsuspended MMF therapy and 13.31-/+2.98 days in those with reduced or suspended MMF (P<0.05); the former patients required subsequently 62.7-/+3.23 days to recover normal liver function and the latter need only 23.4-/+2.29 days (P<0.05).</p><p><b>CONCLUSION</b>MMF should be reduced or suspended when liver function abnormality occurred in patients with hepatitis C after kidney transplantation, and immediate intravenous therapy for liver protection may prove beneficial.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Período Pós-Operatório
/
Cirurgia Geral
/
Uremia
/
Seguimentos
/
Transplante de Rim
/
Hepatite C
/
Usos Terapêuticos
/
Tratamento Farmacológico
/
Imunossupressores
/
Testes de Função Hepática
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Journal of Southern Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo