Mutations of mitochondrial tRNAand their connection with hearing loss / 中华医学遗传学杂志
Chinese Journal of Medical Genetics
; (6): 128-132, 2017.
Article
em Zh
| WPRIM
| ID: wpr-335167
Biblioteca responsável:
WPRO
ABSTRACT
Mitochondrial tRNAgene mutation is closely related to acoustic nerve deafness. Some mutations can affect the structure and transcriptional processing of tRNA, for instance m.7444G>A mutation in tRNAprecursor 3' side, m.7472 insC as well as m.7511T>C mutations in the stem and ring of tRNA, may influence tRNAstability, thus affect the synthesis of mitochondrial peptides, reduce the production of ATP and cause deafness. This article focuses on mitochondrial tRNAgene mutations as well as the mechanism underlying hearing loss.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
RNA
/
RNA de Transferência de Serina
/
Sequência de Bases
/
Química
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Sequência de Aminoácidos
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Predisposição Genética para Doença
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Proteínas Mitocondriais
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Genética
/
Perda Auditiva
/
Mutação
Limite:
Humans
Idioma:
Zh
Revista:
Chinese Journal of Medical Genetics
Ano de publicação:
2017
Tipo de documento:
Article