Research progress in hydroxylase in taxol biosynthetic pathway / 生物工程学报
Chinese Journal of Biotechnology
; (12): 554-564, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-337442
Biblioteca responsável:
WPRO
ABSTRACT
Taxol is a secondary metabolite with prominent anti-tumor activity, but the yield cannot meet the growing clinical demand due to lower content in yew. Now, most enzyme genes involved in taxol biosynthesis have been cloned and identified, so that obtaining this drug by using synthetic biology method has become a hotspot in recent years. However, most hydroxylases involved in taxol biosynthetic pathway have not been explored. Here, we reviewed the progress on the biosynthesis pathway of taxol, especially concerning hydroxylase. The future research areas of taxol biosynthesis through synthetic biology were also discussed to provide basis for the discovery of uncharacterized hydroxylase genes and the mass taxol production by synthetic biology technology.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Paclitaxel
/
Taxus
/
Vias Biossintéticas
/
Biologia Sintética
/
Oxigenases de Função Mista
/
Metabolismo
Idioma:
Chinês
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2016
Tipo de documento:
Artigo