Relationship between ALDH gene polymorphism and alcoholic liver diseases / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 654-656, 2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-339130
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the relationship between aldehyde dehydrogenase (ALDH) gene polymorphism and alcoholic liver disease, and investigate the genetic pathogenesis of alcoholic liver disease (ALD).</p><p><b>METHODS</b>PCR, restriction endonuclease and electrophoresis were used, to detect the genotypes and alleles frequencies of ALDH gene in patients in the control group, alcohol dependent group and ALD group, and each group contained 20 patients.</p><p><b>RESULTS</b>The frequencies of ALDH2*1 and ALDH2*2 allele had statistic significance between control group and ALD group (x2=4.80, P<0.05), and no statistic significance between control group and alcohol dependent group. ALDH2*1/*1 was predominant in alcohol dependent group and ALD group, while ALDH2*2/*2 was not detected.</p><p><b>CONCLUSIONS</b>The gene polymorphism of ALDH is close to ALD. The allele of ALDH2*2 may be a negative risk factor for the developing of ALD</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Fatores de Risco
/
Aldeído Desidrogenase
/
Alelos
/
Frequência do Gene
/
Genética
/
Hepatopatias Alcoólicas
Tipo de estudo:
Estudo de etiologia
/
Fatores de risco
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2003
Tipo de documento:
Artigo