Effects of penile vasoactive mediators on the development of erectile dysfunction / 中华男科学杂志

ABSTRACT

Penile corpus cavernosum can be seen as a special kind of vascular structure. The cause of erectile dysfunction (ED) is often related to the changes of penile vasoactive mediators which modulate the functional conditions of penile erectile tissues. The penile vasoactive mediators including angiotensin and kinins, prostaglandins, endothelins, endothelium-derived hyperpolarizing factors (EDHF), NOS and NO, RhoA/Rho-kinases, etc., may play an important role in the development of ED. Further researches on these mediators can furnish some theoretical evidence for the clinical treatment of ED.