Influence of estradiol benzoate on fluid reabsorption capacity of rat efferent ductuli / 中华男科学杂志
National Journal of Andrology
; (12): 806-809, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-339421
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the influence of estradiol benzoate (E2B) on the fluid reabsorption capacity of rat efferent ductuli.</p><p><b>METHODS</b>Newborn male Sprague-Dawley rats were injected subcutaneously with E2B (0.2 mg/5 g body weight), and the histological morphology of efferent ductulus, epithelial ultrastructure, and immunoexpression of AQP-1 were investigated on postnatal day 14, 21, 28, 42 and 56, respectively. Vehicle was given to the controls.</p><p><b>RESULTS</b>After exposure to E2B, the lumina of the efferent ductuli dilated greatly (P < 0.05), and the epithelium height decreased significantly (P < 0.01), microvilli of nonciliated cells short and sparse, endocytic apparatus implicated in fluid reabsorption scarce, and with no AQP-1 expression.</p><p><b>CONCLUSION</b>High dosage of E2 B neonatally administrated to rats damages the fluid reabsorption capacity of efferent ductuli.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fisiologia
/
Testículo
/
Líquidos Corporais
/
Ratos Sprague-Dawley
/
Absorção
/
Células Epiteliais
/
Estradiol
/
Aquaporina 1
/
Toxicidade
/
Animais Recém-Nascidos
Limite:
Animais
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2005
Tipo de documento:
Artigo