Influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal ischemia - reperfusion(I/R) injury / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 213-215, 2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-339635
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To study the influence of astragalus and zinc sulfate on the viscosity in erythrocyte membrane during intestinal I/R and their mechanism of action.</p><p><b>METHODS</b>Models of rabbits intestinal I/R injury were made. The effect of astragalus and zinc sulfate on the viscosity and malondialdehyde (MDA) in erythrocyte membrane, superoxide dismutase (SOD) in erythrocyte, oxidase (XO) in plasma and MDA tissues homogenate were observed.</p><p><b>RESULTS</b>The administration of astragalus and zinc sulfate decreased viscosity and MDA and XO, prevented the reduction of SOD, and alleviated I/R injury.</p><p><b>CONCLUSION</b>Lipid peroxidation injury of the erythrocyte membrane was one of the pathogenesis of I/R injury, and astragalus and the zinc sulfate possessed effects of anti-lipid peroxide, stabilized erythrocyte membrane, increased red blood cell deform ability and raised microcircular perfusion.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredutases
/
Patologia
/
Farmacologia
/
Superóxido Dismutase
/
Viscosidade Sanguínea
/
Medicamentos de Ervas Chinesas
/
Peroxidação de Lipídeos
/
Traumatismo por Reperfusão
/
Sulfato de Zinco
/
Astrágalo
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2003
Tipo de documento:
Artigo