Effect of anions and anion channel blockers on vascular tone in rat aorta / 中国应用生理学杂志

ABSTRACT

<p><b>AIM</b>To investigate the action of anions and anion channel blockers in the regulation of vascular contraction induced by norepinephrine (NE).</p><p><b>METHODS</b>NE-induced contraction was observed in rat aorta by using routine blood vascular perfusion in vitro.</p><p><b>RESULTS</b>The anion channel blockers niflumic acid (NFA) and 5-nitro-2-(3-phenoxylpropylamino)-benzoic acid (NPPB) produced inhibitory effects on NE-evoked contractions in the aorta. NE-induced contraction was not significantly changed after the extracellular Na+ was replaced by choline, in contrast, the vascular was relaxed when the extracellular Cl- was replaced by glutamate. Moreover, the vasoconstriction induced by NE was further enhanced with the replacement of the extracellular Cl- by Br-, which was still sensitive to either NFA or NPPB.</p><p><b>CONCLUSIONS</b>Anion channels play an important role in the regulation of blood vascular tone, which may be responsible for the salt-sensitivity hypertension.</p>