Urinary excretion pattern of 2-thio-thiazolidine-4-carboxylic acid in workers exposed to carbon disulfide / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 426-428, 2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-340054
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the urinary excretion pattern for of 2-thio-thiazolidine-4-carboxylic acid (TTCA) in workers exposed to CS2, so as to provide experimental basis for working out biomonitoring measures for short-term exposure to CS2.</p><p><b>METHODS</b>Sixty-nine subjects were divided into three groups (1) fourteen volunteers who had not been exposed to CS2 before were exposed to CS2 for 2 hours, their urine samples were collected and analyzed at different time points; (2) The urine samples of 15 occupational exposure workers were collected on pre-shift, mid-shift, post-shift; (3) The relationship between 8 h time weighted average CS2 exposure concentrations (PC-TWA) and TTCA levels of post-shift urine was studied among 40 workers chronically exposed to CS2.</p><p><b>RESULTS</b>(1) In the 1st group, urine TTCA level reached the peak [(1.03 +/- 0.72) mg/gCr] 4 h after exposure; (2) In the 2nd group, urine TTCA level on pre-shift [(0.37 +/- 0.28) mg/gCr] was lower than that on mid-shift [(1.23 +/- 0.71) mg/gCr, P<0.01] and post-shift [(1.31 +/- 0.78) mg/gCr, P<0.01]; (3) In the 3rd group, there was a linear relationship between the post-shift urine TTCA level and 8 h CS2 exposure concentrations dose (PC-TWA). The regression equation is Y(TTCA mg/gCr)=1.163 6X(CS2 mg/m3)-5.411 6.</p><p><b>CONCLUSION</b>The post-shift urine TTCA levels may be regarded as a bio-monitoring index for workers exposed to CS2.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Exposições Ocupacionais
/
Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tiazóis
/
Urina
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Dissulfeto de Carbono
/
Monitoramento Ambiental
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Exposição Ocupacional
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Tiazolidinas
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Metabolismo
Limite:
Adulto
/
Humanos
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Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2003
Tipo de documento:
Artigo