The relationship between hemoglobin adducts of trinitrotoluene and exposed level / 中华劳动卫生职业病杂志
Chinese Journal of Industrial Hygiene and Occupational Diseases
; (12): 189-191, 2002.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-340100
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the biomarkers for monitoring trinitrotoluene (TNT) exposure, the relationship between TNT hemoglobin adducts and TNT exposed level.</p><p><b>METHOD</b>Hemoglobin adducts (4A-Hb and 2A-Hb) were determined by GC-MS in 25 TNT exposed workers. TNT exposed level was evaluated by determining skin contaminated and inhaled TNT levels. The correlation between hemoglobin adducts level and TNT exposed level was analyzed.</p><p><b>RESULTS</b>There was a correlation between total TNT exposure level, especially skin exposure level, and 4A-Hb or 2A-Hb content. No significant difference was found between the slopes and intercepts of lin ear equation of (4A-Hb) vs TNT exposed level and linear equation of (4A-Hb +2A-Hb) vs TNT exposed level (P > 0.05).</p><p><b>CONCLUSION</b>Skin contamination is the major role of TNT exposure. TNT exposed level can be evaluated by determining the content of both 4A-Hb and 2A-Hb, and 4A-Hb is more suitable for monitoring TNT exposure.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.9 Reduzir as mortes por produtos químicos y contaminação do ar, água e solo
/
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Exposições Ocupacionais
/
Meta 3.9: Reduzir o número de mortes por produtos químicos perigosos e contaminação do ar e água do solo
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pele
/
Trinitrotolueno
/
Hemoglobinas
/
Monitoramento Ambiental
/
Exposição Ocupacional
/
Metabolismo
/
Métodos
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Industrial Hygiene and Occupational Diseases
Ano de publicação:
2002
Tipo de documento:
Artigo