Association between IL-19 gene polymorphisms and hepatitis B virus susceptibility in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1277-1281, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-340525
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between the single nucleotide polymorphisms (SNP) of interleukin (IL)-19 and susceptibility to hepatitis B virus (HBV) infection in children.</p><p><b>METHODS</b>A case-control study was performed, and 136 children with positive HBsAg(case group) and 297 healthy children with negative HBsAg(control group) were enrolled. PCR and DNA sequencing were used for genotyping.</p><p><b>RESULTS</b>There were significant differences in the frequencies of genotypes of IL-19 rs1798 between the case and control groups. The case group also had a significantly higher proportion of children with CG genotype than the control group (p<0.05). There were significant differences in the frequencies of genotypes and alleles of IL-19 rs2243191 between the HBV infection and non-infection groups among children who born to HBV-positive mothers. The infection group had significantly higher proportions of children with TC and CC genotypes and C allele than the non-infection group (p<0.05).</p><p><b>CONCLUSIONS</b>The SNP of IL-19 rs1798 may be associated with susceptibility to hepatitis B in children, and the SNP of IL-19 rs2243191 may be associated with susceptibility to breakthrough HBV infection in children at a high risk of HBV infection.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Interleucinas
/
Predisposição Genética para Doença
/
Polimorfismo de Nucleotídeo Único
/
Genética
/
Genótipo
/
Hepatite B
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2016
Tipo de documento:
Artigo