Association between tumor necrosis factor-α G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 1247-1253, 2016.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-340531
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the association between tumor necrosis factor-α (TNF-α) G-308A polymorphisms and genetic susceptibility to spontaneous preterm birth (SPTB).</p><p><b>METHODS</b>The case group enrolled 753 SPTB infants and the control group included 681 term infants. TNF-α G-308A polymorphisms were genotyped using Sequenom MassARRAY®SNP.</p><p><b>RESULTS</b>The frequencies of the allele (G and A) in the case and control groups were not significantly different (P=0.35). The frequencies of the genotypes (GG, GA and AA) in the case and control groups were not significantly different (P=0.64). The logistic regression analysis found that TNF-α G-308A was not associated with genetic susceptibility to SPTB (OR=0.85; 95%CI 0.61-1.19; P=0.35).</p><p><b>CONCLUSIONS</b>There is no association between the polymorphisms of TNF-α G-308A and the genetic susceptibility to SPTB.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fator de Necrose Tumoral alfa
/
Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Nascimento Prematuro
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Genética
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Genótipo
Limite:
Feminino
/
Humanos
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Masculino
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Recém-Nascido
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2016
Tipo de documento:
Artigo