Effects of ruthenium red on body temperature in rats with lipopolysaccharide-induced fever / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the effect of ruthenium red (RR) on the body temperature of rats with lipopolysaccharide (LPS)-induced fever and investigate the possible mechanism.</p><p><b>METHODS</b>Rat models of fever were established with lipopolysaccharide and the effects of RR at different doses were observed on the body temperature of the rats and the content of TRPV4 in the hypothalamus.</p><p><b>RESULTS</b>Compared with those in LPS group, the rats with LPS-induced fever receiving RR treatment showed a dose-dependent lowering of the body temperature. The rats with RR treatment had lower body temperature than those with saline injection. The content of TRPV4 in the saline group was significantly higher than that in RR+LPS and RR group.</p><p><b>CONCLUSIONS</b>RR inhibits LPS-induced fever in rats and regulates the hypothalamal expression of TRPV4 channels, which may participate in the maintenance of normal body temperature.</p>