Association between C-reactive protein gene +1059 G/C polymorphism and the risk of coronary heart disease: a meta-analysis / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 4780-4785, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-341741
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>C-reactive protein (CRP) gene +1059 G/C polymorphism has been reported to be associated with coronary heart disease (CHD) risk, but the results remain inconclusive. This meta-analysis was therefore conducted to clarify these controversies.</p><p><b>METHODS</b>A comprehensive search was conducted to identify all case control studies on the association between CRP gene +1059 G/C polymorphism and CHD risk. All the related studies were further strictly selected according to the inclusion criteria. Meta-analysis was performed with STATA 10.1 (StataCorp, USA). The association was assessed by odds ratio (OR) and 95% confidence interval (CI); both Begg's funnel plot and Egger's regression test were used to assess the publication bias.</p><p><b>RESULTS</b>This meta-analysis on a total of 13 studies comprising 6316 CHD cases and 4467 controls showed no significant association between CRP gene +1059 G/C polymorphism and CHD risk in the overall study (for C/C+C/G vs. G/G OR = 1.01, 95% CI = 0.81-1.25, P = 0.96; for C/C vs. C/G+G/G OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C/C vs. G/G OR = 1.17, 95% CI = 0.77-1.77, P = 0.47; for C allele vs. G allele OR = 1.01, 95% CI = 0.81-1.24, P = 0.96). However, in the subgroup analysis by ethnicity, the results showed significant association between CRP gene +1059 G/C polymorphism and CHD risk among Caucasians (for C/C vs. G/G OR = 2.54, 95% CI = 1.13-5.72, P = 0.02; C/C vs. C/G+G/G OR = 2.45, 95% CI = 1.09-5.51, P = 0.03), but not among Asians and Africans (P > 0.05).</p><p><b>CONCLUSION</b>CRP gene +1059 G/C polymorphism may be associated with increased CHD risk among Caucasians and more evidences need to validate the conclusion.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Proteína C-Reativa
/
Doença das Coronárias
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Predisposição Genética para Doença
/
Genética
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
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Estudo prognóstico
/
Fatores de risco
/
Revisão sistemática
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo