Expression of c-myc mRNA on early restenosis after carotid endarterectomy / 中华外科杂志
Chinese Journal of Surgery
; (12): 555-557, 2007.
Article
em Zh
| WPRIM
| ID: wpr-342122
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the expression and changes of protooncogene c-myc in early restenosis after carotid endarterectomy (CEA).</p><p><b>METHODS</b>Using New Zealand Rabbits, carotid atherosclerotic stenosis (CASS) model were created. The expression of c-myc in early restenosis after CEA were detected by quantitative real-time polymerase chain reaction (qRT-PCR).</p><p><b>RESULTS</b>In this experiment protooncogene c-myc was analysed at pre-operation, 4 hours and 1 d after CEA by qRT-PCR, and the level of mRNA of c-myc was reached maximum at 4 hours, and decreased following significantly, but still higher than pre-operation.</p><p><b>CONCLUSIONS</b>The activation of protooncogene c-myc may be generator factor of vascular smooth muscle cell proliferation.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Patologia
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Complicações Pós-Operatórias
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Cirurgia Geral
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RNA Mensageiro
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Artérias Carótidas
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Doenças das Artérias Carótidas
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Distribuição Aleatória
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Expressão Gênica
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Proteínas Proto-Oncogênicas c-myc
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Endarterectomia das Carótidas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Ano de publicação:
2007
Tipo de documento:
Article