Study on thermo-sensitive intelligent targeting type drug carriers (I) porous membranes with grafted thermo-sensitive gates / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 791-794, 2004.
Article
em Zh
| WPRIM
| ID: wpr-342610
Biblioteca responsável:
WPRO
ABSTRACT
Thermo-responsive intelligent membranes with linear grafted poly(N-isopropylacrylamide) (PNIPAM) gates on the inner pore surface were prepared, and experiments were carried out on the thermo-responsive gating characteristics. Plasma-graft pore-filling polymerization was used to graft PNIPAM into the pore of the porous flat membranes. The experimental results showed that PNIPAM-grafted PVDF (PNIPAM-g-PVDF) membranes were featured with thermo-responsiveness due to the thermo-responsive swollen-shrunken property of PNIPAM chains grafted on the inner pore surface of the membrane. At temperatures below the lower critical solution temperature (LCST), the linear grafted PNIPAM chains on the inner pore surface were in the swollen state, and the pores in the membrane were closed; in contrast, the grafted PNIPAM chains were in the shrunken state at temperatures above the LCST, and therefore the pores in the membrane were open. The LCST of the thermo-sensitive gates could be adjusted by adding acrylamide (AAM) in the N-isopropylacrylamide (NIPAM) monomer solution, the LCST of the poly(NIPAM-co-AAM) gates increased simply with the increase of the AAM fraction.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Temperatura
/
Resinas Acrílicas
/
Portadores de Fármacos
/
Porosidade
/
Sistemas de Liberação de Medicamentos
/
Membranas Artificiais
/
Métodos
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Zh
Revista:
Journal of Biomedical Engineering
Ano de publicação:
2004
Tipo de documento:
Article