Regulatory genes of geldanamycin biosynthesis / 生物工程学报
Chinese Journal of Biotechnology
; (12): 717-722, 2008.
Article
em Zh
| WPRIM
| ID: wpr-342845
Biblioteca responsável:
WPRO
ABSTRACT
Two LAL family regulatory genes, gdmRI and gdmRII, were identified in the geldanamycin biosynthetic gene cluster of Streptomyces hygroscopicus 17997. Disruption of the two regulatory genes resulted in absolute elimination of geldanamycin biosynthesis. The complementation experiments using a single wild-type gene could restore geldanamycin production. These results indicated that both gdmRI and gdmRII were positive regulatory genes of the geldanamycin biosynthesis.
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Proteínas Repressoras
/
Streptomyces
/
Proteínas Tirosina Quinases
/
Regulação Bacteriana da Expressão Gênica
/
Transativadores
/
Benzoquinonas
/
Proteínas de Choque Térmico HSP90
/
Lactamas Macrocíclicas
/
Genética
/
Metabolismo
Tipo de estudo:
Prognostic_studies
Idioma:
Zh
Revista:
Chinese Journal of Biotechnology
Ano de publicação:
2008
Tipo de documento:
Article