Synthesis and in vitro cytotoxicity of naphthalimide polyamine conjugates as antitumor agents / 药学学报
Acta Pharmaceutica Sinica
; (12): 754-757, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-344111
Biblioteca responsável:
WPRO
ABSTRACT
Six naphthalimide polyamine conjugates were synthesized and their structures were confirmed by elemental analysis, 1H NMR, 13C NMR and MS. Antitumor activities were evaluated in vitro using MTT assay on Leukemia cells (K562), human breast cancer cells (MB-231) and prostate cancer cells (Ln cap cell). The results showed that most of the six compounds were superior to the control (amonafide), 6d, 6e, and 6f exhibited nice selectivity in a screen of hepatoma cells (BEL-7402) and human normal hepatocytes (QSG-7701).
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Poliaminas
/
Estrutura Molecular
/
Linhagem Celular Tumoral
/
Naftalimidas
/
Antineoplásicos
Limite:
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2009
Tipo de documento:
Artigo