C1772T polymorphism of hypoxia-inducible factor-1 alpha gene in Han ethnic population from Northern China / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 267-270, 2008.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-344338
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the distribution of single nucleotide polymorphism C1772T (SNP/C1772T) in hypoxia-inducible factor -1 alpha (HIF-1 alpha) gene in Han ethnic population from Northern China.</p><p><b>METHODS</b>Allele frequencies in a sample of 206 healthy Chinese Hans were determined by polymerase chain reaction followed by restriction fragment length polymorphism.</p><p><b>RESULT</b>The genotype frequencies of C1772T observed in Chinese Hans were 93 % and 7% for CC and CT respectively; and allele frequencies were 96% and 4 %for C and T respectively. There was significant difference in distribution of allele frequencies between Chinese Hans and Caucasian.</p><p><b>CONCLUSION</b>The single nucleotide polymorphism of C1772T in HIF-1 alpha gene has difference in different ethnic population.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
China
/
Polimorfismo de Nucleotídeo Único
/
Subunidade alfa do Fator 1 Induzível por Hipóxia
/
Etnologia
/
Frequência do Gene
/
Genética
/
Genótipo
Limite:
Adolescente
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Chinês
Revista:
Journal of Zhejiang University. Medical sciences
Ano de publicação:
2008
Tipo de documento:
Artigo