Antidepressant-like effects of piperine and its neuroprotective mechanism / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1562-1565, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-344580
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the antidepressant effect of piperine and its neuroprotective mechanism.</p><p><b>METHOD</b>The behavioral studies were performed in forced swimming test (FST) and tail suspension test (TST). To further explore the mechanisms underlying their antidepressant-like activities, CORT-induced neuroblastoma SH-SY5Y cells and isolated and cultured neural progenitor cells. By using MTT assay, the effect of piperine on neural cells proliferation was observed.</p><p><b>RESULT</b>The research results indicated that after a week of administration, piperine (10, 20 mg x kg(-1)) could significantly reduce the duration of immobility in both FST and TST. Piperine has the protective effect on neuroblastoma cells and increased proliferation of hippocampus neural progenitor cells.</p><p><b>CONCLUSION</b>In the present study, we demonstrated that the antidepressant-like effects of piperine and its mechanisms might be involved by up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Piperidinas
/
Células-Tronco
/
Distribuição Aleatória
/
Linhagem Celular
/
Células Cultivadas
/
Fármacos Neuroprotetores
/
Biologia Celular
/
Proliferação de Células
/
Alcaloides
/
Benzodioxóis
Limite:
Animais
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo