Effect of glutamine and growth hormone on adaptation in short bowel syndrome / 中华胃肠外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To assess the effects of parenteral glutamine and growth hormone supplementation on gut adaptation for patients with short bowel syndrome.</p><p><b>METHODS</b>Twenty-six patients [male 15, female 11, aged (39 +/- 23) years] with short bowel syndrome received parenteral nutrition (PN) 3-52 months after surgical resection. The median length of remnant small intestine was 42.5(0-100)cm. All patients received growth hormone (0.10+/- 0.06) mg.kg(-1).d(-1) plus glutamine (0.30 +/- 0.17) mg.kg(-1).d(-1) for two or three weeks.</p><p><b>RESULTS</b>Among the 26 patients, PN was not required soon after treatment in 34.6% (n=9) of the patients, the frequency and volume of PN decreased from (6.0 +/- 1.0) d to (4.2 +/- 1.0) d, from (13.6 +/- 5.2) L per week to (8.2 +/- 3.3) L per week respectively in 30.8% (n=8) of the patients,while 34.6% (n=9) still required PN after treatment.</p><p><b>CONCLUSION</b>The combined administration of glutamine and growth hormone can promote remnant intestinal adaptation in short bowel patients.</p>