Chemical constituents of Periploca forrestii and their cytotoxicity activity / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3214-3216, 2009.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-346914
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities.</p><p><b>METHOD</b>Silica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62).</p><p><b>RESULT</b>Four compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin (4).</p><p><b>CONCLUSION</b>Compound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Farmacologia
/
Triterpenos
/
Medicamentos de Ervas Chinesas
/
Estrutura Molecular
/
Sobrevivência Celular
/
Química
/
Raízes de Plantas
/
Células HL-60
/
Concentração Inibidora 50
/
Periploca
Limite:
Humanos
Idioma:
Inglês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2009
Tipo de documento:
Artigo