Influence of super high molecular weight poly D,L-lactic acid on viability and new bone formation of osteoblasts / 中华口腔医学杂志
Chinese Journal of Stomatology
; (12): 67-69, 2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-347302
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of the viability and new bone formation of osteoblasts by the super high molecular weight poly D,L-lactic acid (SHMW-PDLLA).</p><p><b>METHODS</b>1. The osteoblasts derived from neonatal rat were grown and maintained at steep of SHMW-PDLLA and normal culture medium. The viability and function of the osteoblasts were measured with MTT array. 2. The plate and screws made of SHMW-PDLLA were implanted and fixed at the artificial fractured mandible of dogs. Specimens were gained at 3 and 6 months and examined with macroscopy and SEM.</p><p><b>RESULTS</b>1. There is no significant difference of OD values between the experimental group and the control group (P > 0.05). The SHMW-PDLLA isn't toxic to osteoblast at 1 week and 2 weeks, and the toxicity is 3% at 3 days. 2. There were a lot of new bone formed between the implanted SHMW-PDLLA plate and bone tissues under SEM.</p><p><b>CONCLUSION</b>SHMW-PDLLA hasn't pathological influence on the viability and new bone formation of osteoblasts and it is feasible in tissue engineering of bone.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Osteoblastos
/
Osteogênese
/
Farmacologia
/
Poliésteres
/
Polímeros
/
Cirurgia Geral
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Placas Ósseas
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Parafusos Ósseos
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Microscopia Eletrônica de Varredura
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Sobrevivência Celular
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Journal of Stomatology
Ano de publicação:
2003
Tipo de documento:
Artigo