Correlation between ABO blood type gene and attention-deficit hyperactivity disorder in children / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 371-373, 2009.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-347912
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the correlation between ABO blood type gene and attention-deficit hyperactivity disorder (ADHD) in children.</p><p><b>METHODS</b>ABO blood types were determined using glass sheet method in 96 children with ADHD and their parents. O gene was identified using polymerase chain reaction and restriction fragment length polymorphism in patients with A or B blood type. Haplotype-based haplotype relative risk (HHRR), transmission-disequilibrium test (TDT) and Chi-square test were used to examine the association between ABO gene and ADHD.</p><p><b>RESULTS</b>TDT results showed significant differences in the allele of ABO between the 96 children with ADHD and within-family controls (chi2=6.017, df=2, P< 0.05). Chi-square test results showed differences in the allele of A and B (chi2=3.289, df=1, P=0.07) as well as O and B (chi2=3.629, df=1, P=0.057 ) between ADHD children and within-family controls. The frequencies of O and A genes were higher than that of B gene in ADHD children.</p><p><b>CONCLUSIONS</b>There was correlation between ABO blood type gene and ADHD in children. The risk of ADHD is increased in the presence of alleles O and A, but the risk is reduced in the presence of allele B.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Transtorno do Deficit de Atenção com Hiperatividade
/
Sangue
/
Sistema ABO de Grupos Sanguíneos
/
Haplótipos
/
Alelos
/
Genética
Tipo de estudo:
Estudo de etiologia
/
Estudo prognóstico
Limite:
Adolescente
/
Criança
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Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2009
Tipo de documento:
Artigo