Beta -transduction repeat containing protein expressed in tooth germs and ameloblast and odontoblast of different stage of tooth development / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 195-197, 2007.
Article
em Zh
| WPRIM
| ID: wpr-348065
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The Sonic hedgehog signalling peptide has been demonstrated to play important roles in the growth and patterning of the tooth development. This study aims on whether the antagonist beta-transduction repeat containing protein of Sonic hedgehog signal transduction expressed in tooth germs ameloblast and odontoblast or not.</p><p><b>METHODS</b>The mouse embryo heads of different developmental stages of E10.5, E13.5, E14.5, E16.5, E18.5 and P0, P3, P6 after birth were acquired fixed with 4% paraformaldehyde for 48 hours, embeded with Paraffin and examined using LsAB (labelled streptavidin-biotin) method to observe the beta-TrCP expression pattern in tooth germs, ameloblast and odontoblast.</p><p><b>RESULTS</b>It was demonstrated that beta-TrCP expressed in oral epithelium, tooth bud, mesenchymal cell cytoplasm of ameloblast and odontoblast of different stage of tooth development.</p><p><b>CONCLUSION</b>beta-TrCP expressed from early stage to later stage of murine tooth development. And these findings provide the evidence of antagonist regulatory pathways for shh in teeth development.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Germe de Dente
/
Transdução de Sinais
/
Ameloblastos
/
Odontoblastos
/
Odontogênese
Limite:
Animals
Idioma:
Zh
Revista:
West China Journal of Stomatology
Ano de publicação:
2007
Tipo de documento:
Article