Effects of acupuncture on expressions of transcription factors NF-E2, YB-1, LRG47 in the SAMP10 mouse / 中国针灸
Chinese Acupuncture & Moxibustion
; (12): 651-654, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-348476
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the mechanism of acupuncture in delaying aging.</p><p><b>METHODS</b>Using SAMP10 mice and normal control SAMR1 as model and applying RT-PCR and DIG probed Northern blot techniques to observe expression of NF-E2, YB-1, LRG47 genes in whole brain, cortex and hippocampus in the 8-month SAMR1 control group, 8-month SAMP10 control group, 8-month SAMP10 acupuncture group and 8-month SAMP10 non-point acupuncture group.</p><p><b>RESULTS</b>In the SAMP10 control group, the expression of NF-E2, YB-1 and LRG47 were down-regulated in the whole brain, cortex and hippocampus, and after acupuncture they were up-regulated and tended to normal.</p><p><b>CONCLUSION</b>Aging of the SAMP10 mouse brain is related with expression of NF-E2, YB-1 and LRG47 genes, and acupuncture can regulate the expression of NF-E2, YB-1 and LRG47 genes, improving the functions of erythrocyte series, increasing proliferation of cells and immune function of cells in anti-bacteria, hence anti-aging.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Encéfalo
/
Envelhecimento
/
RNA Mensageiro
/
Terapia por Acupuntura
/
Regulação da Expressão Gênica
/
Proteínas de Ligação ao GTP
/
Proteína 1 de Ligação a Y-Box
/
Subunidade p45 do Fator de Transcrição NF-E2
/
Genética
/
Metabolismo
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Chinês
Revista:
Chinese Acupuncture & Moxibustion
Ano de publicação:
2006
Tipo de documento:
Artigo