Microbial glycosylation of cardamonin by Mucor spinosus / 药学学报
Acta Pharmaceutica Sinica
; (12): 733-737, 2011.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-348892
Biblioteca responsável:
WPRO
ABSTRACT
Microbial transformation of cardamonin by Mucor spinosus (CGMCC 3.3450) in preparative scale resulted in the isolation of two new products. Their structures were elucidated unambiguously by ESI-MS, 1H NMR, 13C NMR and 2D NMR spectra analyses as 4-O-beta-D-glucopyranosyl-6-hydroxy-2-methoxychalcone (1, 4-GluC) and 6-O-beta-D-glucopyranosyl-4-hydroxy-2-methoxychalcone (2, 6-GluC), respectively. The time-course of biotransformation by M. spinosus showed that both 4-GluC and 6-GluC appeared on the 2nd day. The optimal biotransformation temperature was 28 degrees C, the optimal biotransformation time was 72 h and the optimal concentration for cardamonin was 40 mg x mL(-1). This is the first time for successful microbial glycosylation of cardamonin in present research.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Glicosilação
/
Biotransformação
/
Espectroscopia de Ressonância Magnética
/
Estrutura Molecular
/
Química
/
Espectrometria de Massas por Ionização por Electrospray
/
Chalconas
/
Glucosídeos
/
Metabolismo
/
Mucor
Idioma:
Inglês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2011
Tipo de documento:
Artigo