A study of the association of iNOS and eNOS gene polymorphism with portal hypertension in liver cirrhosis / 中华肝脏病杂志
Chinese Journal of Hepatology
; (12): 366-369, 2005.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-349109
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study whether polymorphism of iNOS and eNOS genes is associated with portal hypertension in liver cirrhosis.</p><p><b>METHODS</b>A case control study of 106 patients with liver cirrhosis due to HBV was performed in comparison with 108 controls using PCR-RFLP to detect iNOS promoter -969G --> C and eNOS exon7 894G --> T polymorphism.</p><p><b>RESULTS</b>The frequency of the C allele and GC genotype in the iNOS promoter -969G --> C was significantly higher in the portal hypertension group than in the control group. (P < 0.05). The frequency of the T allele and GT genotype in eNOS exon7 894G --> T was dramatically higher in the portal hypertension group than in the control group (P < 0.05). Multivariate logistic regression analysis revealed that iNOS polymorphism in iNOS promoter -969G --> C and eNOS exon7 894G --> T was an independent new risk factor for portal hypertension. We discovered that iNOS promoter -969G --> C led to an increase in its functional activity.</p><p><b>CONCLUSIONS</b>The polymorphism of iNOS promoter -969G --> C and eNOS exon7 894G --> T is associated with portal hypertension of liver cirrhosis, which is a new independent risk factor found related to the occurrence of portal hypertension. The polymorphism of iNOS promoter -969G --> C results in functional activity increase of the iNOS promoter.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Polimorfismo de Fragmento de Restrição
/
Reação em Cadeia da Polimerase
/
Regiões Promotoras Genéticas
/
Hepatite B Crônica
/
Óxido Nítrico Sintase Tipo II
/
Óxido Nítrico Sintase Tipo III
/
Genética
/
Hipertensão Portal
/
Cirrose Hepática
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
Chinese Journal of Hepatology
Ano de publicação:
2005
Tipo de documento:
Artigo