Association between fibroblast growth factor 3 polymorphism and non-syndromic oral clefting / 华西口腔医学杂志
West China Journal of Stomatology
; (6): 587-590, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-350277
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the association between fibroblast growth factor 3 (FGF3) gene rs4980700 and rs4631909 polymorphism and non-syndromic oral clefting (NSOC).</p><p><b>METHODS</b>Blood samples from 186 NSOC patients, patients' parents and 200 controls were collected. DNA was extracted and PCR-restriction fragment length polymorphism (PCR-RFLP) was used to identify genotypes of the samples. Case-control analyses and transmission disequilibrium test (TDT) and family based association test (FBAT) analyses were also carried out.</p><p><b>RESULTS</b>In case-control analysis, there were significant differences in rs4980700 genotype and allele among NSOC patients compared with the control group (P < 0.05) and there were significant differences in rs4631909 genotype and allele among NSOC patients compared with the control group (P < 0.05), but no difference in cleft palate only (P = 0.49). In TDT, the G allele of rs4980700 had an overtransmission (P < 0.05) and the C allele of rs4631909 had an overtransmission (P < 0.05) in NSOC. FBAT analysis also showed a significant association between FGF3 gene rs4980700, rs4631909 polymorphism and NSOC.</p><p><b>CONCLUSION</b>FGF3 gene rs4980700 and rs4631909 polymorphism were associated with NSOC.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Polimorfismo Genético
/
Reação em Cadeia da Polimerase
/
Fenda Labial
/
Fissura Palatina
/
Alelos
/
Fator 3 de Crescimento de Fibroblastos
/
Genótipo
Tipo de estudo:
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
West China Journal of Stomatology
Ano de publicação:
2010
Tipo de documento:
Artigo