Anti-diabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 2124-2128, 2008.
Article
em En
| WPRIM
| ID: wpr-350789
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Retinol binding protein 4 (RBP4), as an adipocyte secreted cytokine, was recently found to be inversely correlated with expression of glucose transporter 4 (GLUT4) in insulin resistance (IR) state and to have an intimate relationship with IR and type 2 diabetes mellitus (T2DM). The present study aimed to evaluate the anti-diabetic efficacy of cinnamaldehyde (Cin), berberine (Ber), and metformin (Met) as well as their impacts on the RBP4-GLUT4 system.</p><p><b>METHODS</b>Rat models of T2DM were established by combination of intraperitoneal injection of low-dose streptozotocin and high fat diet induction. Rats were divided into five groups: the control group, the diabetes group, the diabetes + Ber group, the diabetes + Cin group, and the diabetes + Met group. Western blotting was used to detect the serum or tissue RBP4 and GLUT4 protein levels.</p><p><b>RESULTS</b>After treatment for four weeks, both Cin and Ber displayed significant hypolipidemic, hypoglycemic, and insulin sensitizing functions (P < 0.01) compared with the control group. Their effects on lowering fasting plasma glucose (FPG), low density lipoprotein-cholesterol (LDL-C) and homeostasis model assessment of insulin resistance (HOMA-IR) seem even better than that of Met. Cin and Ber markedly lowered serum RBP4 levels and up-regulated the expression of tissue GLUT4 protein, and Cin seemed more notable in affecting these two proteins.</p><p><b>CONCLUSIONS</b>Both Cin and Ber display an exciting anti-diabetic efficacy in this study and may be of great value for the treatment of type 2 diabetes. Their mechanisms involve the RBP4-GLUT4 system, during which the serum RBP4 levels are lowered and the expression of tissue GLUT4 protein is up-regulated.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Berberina
/
Acroleína
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Sangue
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Peso Corporal
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Resistência à Insulina
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Western Blotting
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Ratos Wistar
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Usos Terapêuticos
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Diabetes Mellitus Tipo 2
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Tratamento Farmacológico
Limite:
Animals
Idioma:
En
Revista:
Chinese Medical Journal
Ano de publicação:
2008
Tipo de documento:
Article