Y chromosome microdeletions, chromosome karyotypes and reproductive hormones in patients with azoospermia and severe oligozoospermia / 中华男科学杂志
National Journal of Andrology
; (12): 890-895, 2013.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-350817
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlation of azoospermia and severe oligozoospermia with Y chromosome microdeletions, chromosome karyotype and reproductive hormones in male infertility patients.</p><p><b>METHODS</b>We collected semen samples from 63 patients with azoospermia, 49 with severe oligozoospermia and 60 men with normal semen parameters, and determined the incidence of Y chromosome microdeletions, chromosome karyotypes and the levels of reproductive hormones.</p><p><b>RESULTS</b>The incidence rate of Y chromosome microdeletions was 11.11% in the azoospermia and 8.16% in the severe oligozoospermia patients, as compared with 0 in the normal controls (P<0.05). The rate of chromosome abnormalities was 9.52% in the azoospermia group, with statistically significant differences from the severe oligozoospermia and normal control men (both 0) (P<0.05). The levels of FSH and LH were significantly higher in the azoospermia ([20.41 +/- 19.34] IU/L and [11.44 +/- 9.48] IU/L) and the severe oligozoospermia patients ([8.88 +/- 7.04] IU/L and [6.78 +/- 3.85] IU/L) than in the normal males ([3.88 +/- 2.21] IU/L and [4.63 +/- 1.51] IU/L) (P<0.05).</p><p><b>CONCLUSION</b>Examinations of genetics and reproductive hormones are necessary for infertile males with azoospermia and severe oligozoospermia, which may contribute to early diagnosis and treatment.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oligospermia
/
Sêmen
/
Aberrações dos Cromossomos Sexuais
/
Contagem de Espermatozoides
/
Sangue
/
Estudos de Casos e Controles
/
Deleção Cromossômica
/
Cromossomos Humanos Y
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Azoospermia
/
Transtornos do Cromossomo Sexual no Desenvolvimento Sexual
Tipo de estudo:
Estudo observacional
/
Fatores de risco
/
Estudo de rastreamento
Limite:
Adulto
/
Humanos
/
Masculino
Idioma:
Chinês
Revista:
National Journal of Andrology
Ano de publicação:
2013
Tipo de documento:
Artigo