Optimization of formulation of Fufang Danshen immediate release tablet by colligation score / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 380-382, 2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-350936
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To optimize the formulation of immediate release tablet.</p><p><b>METHOD</b>The immediate release tablet was prepared by using dry granules. The preparation was optimized by using orthogonal design which took the flow property of granules, the hardness, the disintegrating time and the dissolution rate of the tablet as indices.</p><p><b>RESULT</b>The optimized formulation contained 40% microcrystalline cellulose, 10% sodium carboxymethyl starch and 15% dextrin. The hardness disintegrating time and T50 of the tablet were 4.5 kg, 3 min, 5 min respectively.</p><p><b>CONCLUSION</b>It is successful to prepare on immediate release tablet using the optimized formula above.</p>
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas Medicinais
/
Solubilidade
/
Comprimidos
/
Medicamentos de Ervas Chinesas
/
Celulose
/
Química
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Salvia miltiorrhiza
/
Dextrinas
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Combinação de Medicamentos
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Composição de Medicamentos
Idioma:
Chinês
Revista:
China Journal of Chinese Materia Medica
Ano de publicação:
2006
Tipo de documento:
Artigo