Effect of Pulsatilla Decoction on the expression of proinflammatory cytokines in inflammatory bowel disease / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 416-419, 2011.
Article
em Zh
| WPRIM
| ID: wpr-351140
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the molecular mechanisms underlying in the treatment of inflammatory bowel disease by Pulsatilla Decoction.</p><p><b>METHODS</b>Forty Wistar male rats were randomly divided into 5 groups( n = 8)control group, model group, model + positive control group (mesalazine), Pulsatilla Decoction treatment group, in addition, the Pulsatilla Decoction treatment group was divided into middle and high dose group. Intragastric administration was used in the positive control group and Pulsatilla Decoction treatment group. The expression of interleukin-1beta (IL-1beta), interleukin-6(IL-6) and tumor necrosis factor-alpha (TNF-alpha) were detected by real time PCR after extraction of RNA from colons.</p><p><b>RESULTS</b>Compared with the model group, positive medicine and Pulsatilla Decoction group, especially high-dose group, could effectively inhibit the expression of IL-1beta, IL-6 and TNF-alpha.</p><p><b>CONCLUSION</b>Pulsatilla Decoction could exert its effect in the treatment of inflammatory bowel disease by inhibiting the expression of proinflammatory cytokines.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Farmacologia
/
RNA Mensageiro
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Medicamentos de Ervas Chinesas
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Doenças Inflamatórias Intestinais
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Química
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Interleucina-6
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Fator de Necrose Tumoral alfa
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Ratos Wistar
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Pulsatilla
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Usos Terapêuticos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Applied Physiology
Ano de publicação:
2011
Tipo de documento:
Article