The relationship between changes in ideal cardiovascular health score and the carotid intima-media thickness among the middle age and elderly population / 中华心血管病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the relationship between changes in ideal cardiovascular health score(&Delta;ICHS) and the carotid intima-media thickness(CIMT) among the middle age and elderly population.</p><p><b>METHODS</b>A total of 5 852 cases were enrolled from 101 510 Kailuan Group employees who participated in the health examination in 2006-2007 and 2010-2011 through stratified random sampling. A total of 5 440 individuals met the inclusion criteria (≥40 years old; no history of stroke, transient ischemic attack, or myocardial infarction). CIMT was measured by ultrasound during 2010-2011 examination. Excluding individuals with incomplete data, 4 367 cases were included for the final analysis. According to the AHA definition of ideal cardiovascular health metric, individual &Delta;ICHS was evaluated and the subjects were divided into 3 groups group reduced (&Delta;ICHS<0, n=1 355), invariant group (&Delta;ICHS=0, n=1 451) and elevated group (&Delta;ICHS>0, n=1 561). &Delta;ICHS was derived from the difference between 2010-2011 and 2006-2007. Multivariate linear regression and logistic regression analysis were used to analysis the relationship between &Delta;ICHS and CIMT.</p><p><b>RESULTS</b>The ICHS was 3.03 ± 1.27 in 2006-2007 study population and 3.09 ± 1.40 (P<0.01) in 2010-2011 study population. Multivariate linear regression analysis showed that &Delta;ICHS was inversely related to CIMT. For every 1 score increase in &Delta;ICHS, CIMT decreased by 0.009 mm(B=-0.009, P<0.01). Multivariate logistic regression analysis showed that after adjusting for multiple confounding factors, the risk of CIMT wall thickening was lower in the &Delta;ICHS invariant group (OR=0.73, 95%CI 0.59-0.91) and in &Delta;ICHS elevated group(OR=0.66, 95%CI 0.52-0.82) compared to the &Delta;ICHS reduce group.</p><p><b>CONCLUSION</b>Elevated &Delta;ICHS is an independent protective factors of CIMT increase in the middle age and elderly population.</p>