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Expression of miR-216a in pancreatic cancer and its clinical significance / 南方医科大学学报
Artigo em Chinês | WPRIM (Pacífico Ocidental) | ID: wpr-352369
Biblioteca responsável: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the clinical significance of miRNA-216a expression in pancreatic cancer.</p><p><b>METHODS</b>Fourteen patients with pancreatic cancer undergoing pancreaticoduodenectomy and 6 patients with benign pancreas lesions were examined for miR-216a expressions in the tumor or lesion tissues using Agilent Human miRNA Microarray (V12.0). The relationship between miR-216a expressions and the clinicopathological features of the patients was analyzed.</p><p><b>RESULTS</b>The expression of miRNA-216a was significantly lower in pancreatic cancer than in benign pancreas lesions (P=0.000). The expression of miRNA-216a was significantly correlated with the T stage of the tumor (P=0.002), but not with the patients' age, gender, smoking status, tumor stage, lymph node metastases, distant metastasis, tumor differentiation, nerve invasion, vessel invasion or serum CA19-9 level (P>0.05).</p><p><b>CONCLUSIONS</b>The down-regulated expression of miR-216a in pancreatic cancer suggests the involvement of miR-216a in the tumorigenesis and development of pancreatic cancer. miR-216a may potentially serve as a novel tumor marker and also a prognostic factor for pancreatic cancer.</p>
Assuntos
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Pancreáticas / Patologia / Adenocarcinoma / MicroRNAs / Genética / Metabolismo / Metástase Neoplásica / Estadiamento de Neoplasias Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2012 Tipo de documento: Artigo
Texto completo: Disponível Base de dados: WPRIM (Pacífico Ocidental) Assunto principal: Neoplasias Pancreáticas / Patologia / Adenocarcinoma / MicroRNAs / Genética / Metabolismo / Metástase Neoplásica / Estadiamento de Neoplasias Tipo de estudo: Estudo prognóstico Limite: Adulto / Idoso / Idoso, 80 anos ou mais / Feminino / Humanos / Masculino Idioma: Chinês Revista: Journal of Southern Medical University Ano de publicação: 2012 Tipo de documento: Artigo
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