Changes in functional connectivity of ventral anterior cingulate cortex in heroin abusers / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1582-1588, 2010.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-352538
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>BACKGROUND</b>Previous studies with animal experiments, autopsy, structural magnetic resonance imaging (MRI) and task-related functional MRI (fMRI) have confirmed that brain functional connectivity in addicts has become impaired. The goal of this study was to investigate the alteration of resting-state functional connectivity of the ventral anterior cingulate cortex (vACC) in the heroin abusers' brain.</p><p><b>METHODS</b>Fifteen heroin abusers and fifteen matched healthy volunteers were studied using vACC as the region-of interest (ROI) seed. A 3.0 T scanner with a standard head coil was the imagining apparatus. T2*-weighted gradient-echo planar imaging (GRE-EPI) was the scanning protocol. A ROI seed based correlation analysis used a SPM5 software package as the tool for all images processing.</p><p><b>RESULTS</b>This study showed a functional connection to the insula vACC in heroin abusers. Compared with controls, heroin users showed decreased functional connectivity between the nucleus accumbens (NAc) and vACC, between the parahippocampala gyrus/amgdala (PHC/amygdala) and vACC, between the thalamus and vACC, and between the posterior cingulated cortex/precuneus (PCC/pC) and vACC.</p><p><b>CONCLUSION</b>The altered resting-state functional connectivity to the vACC suggests the neural circuitry on which the addictive drug has an affect and reflects the dysfunction of the addictive brain.</p>
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
/
ODS3 - Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
Problema de saúde:
Meta 3.5 Prevenção e tratamento do consumo de substâncias psicoativas
/
Abuso de Opioides
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Patologia
/
Imageamento por Ressonância Magnética
/
Giro do Cíngulo
/
Dependência de Heroína
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Chinese Medical Journal
Ano de publicação:
2010
Tipo de documento:
Artigo