Antidepressant amides from Piper laetispicum C. DC / 药学学报
Acta Pharmaceutica Sinica
; (12): 355-357, 2005.
Article
em Zh
| WPRIM
| ID: wpr-353497
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>AIM</b>To investigate the antidepressant constituents of Piper laetispicum C. DC.</p><p><b>METHODS</b>The compounds were enriched by column chromatography on silica gel. Structural determination of the pure compounds was based on extensive analyses of modern spectroscopic methods including MS, HR-MS, UV, IR, 1D- and 2D-NMR spectra. The mouse forced swimming test was used for chasing antidepressant activity.</p><p><b>RESULTS</b>Three amides were isolated and identified as N-isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I), N-isobutyl-9-phenyl-2E, 4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III).</p><p><b>CONCLUSION</b>N-Isobutyl-(3,4-methylendioxyphenyl)-2E, 4E, 9E-undecatrienoamide (I) is a new compound named as laetispicine. N-Isobutyl-9-phenyl-2E, 4E-nonadienamide (II) and N-isobutyl-7-phenyl-2E, 4E-heptadienamide (III) were isolated for the first time as natural substance.</p>
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Plantas Medicinais
/
Estrutura Molecular
/
Química
/
Raízes de Plantas
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Folhas de Planta
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Piper
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Benzodioxóis
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Antidepressivos
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2005
Tipo de documento:
Article