Serratia marcescens vaccine in the treatment of malignant pleural effusion / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 188-190, 2002.
Article
em Zh
| WPRIM
| ID: wpr-354038
Biblioteca responsável:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the efficacy and toxicity of Serratia marcescens (S311) vaccine in the treatment of malignant pleural effusion.</p><p><b>METHODS</b>Thirty-four patients with malignant pleural effusion were given S311 as intrapleural injection with a dose of 10(9) U (0.32 mg) on D 1, 8 and 15, and observed for four weeks.</p><p><b>RESULTS</b>The overall response rate (CR + PR) was 97.1% (CR in 12 patients and PR in 21 patients). The systemic toxicity was mild, including fever (82.4%), pleuritic pain (50.7%), nansea (26.5%), dyspnea (17.5%) and chills (5.9%).</p><p><b>CONCLUSION</b>Serratia marcescens vaccine is effective for malignant pleural effusion, with tolerable toxic effects. Further study is warranted.</p>
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Derrame Pleural
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Serratia marcescens
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Fatores de Tempo
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Dor no Peito
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Vacinas Bacterianas
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Resultado do Tratamento
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Usos Terapêuticos
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Relação Dose-Resposta a Droga
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Tratamento Farmacológico
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Alergia e Imunologia
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Oncology
Ano de publicação:
2002
Tipo de documento:
Article