LC-MSn analysis of metabolites of 1,2-bis (1,2-benzisoselenazolone-3(2H)-ketone)-ethane, a novel anti-cancer agent in rat / 药学学报
Acta Pharmaceutica Sinica
; (12): 627-631, 2010.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-354580
Biblioteca responsável:
WPRO
ABSTRACT
This study is to elucidate the metabolic pathway of 1,2-[bis (1,2-benzisoselenazolone-3 (2H)-ketone)]-ethane (BBSKE) in rats. Rats were administrated with a single dose of BBSKE 200 mg x kg(-1). The metabolites in rat urine, feces, bile and plasma were identified by LC-MSn analysis. The characterization of fragment ions from LC-MSn chromatography and mass spectrometry was applied to the investigation of structures of metabolites. Three phase I metabolites were detected in rat urine and feces. Two of them were also found in plasma and one existed in bile. These products were derived from oxidized, methylated and S-methylated BBSKE, separately. One phase II glucuronide of BBSKE was also found in bile. Therefore, it is possible that BBSKE was metabolized by oxidization, methylation and glucuronidation.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Urina
/
Bile
/
Sangue
/
Química
/
Administração Oral
/
Cromatografia Líquida
/
Compostos Organosselênicos
/
Ratos Sprague-Dawley
/
Compostos Bicíclicos Heterocíclicos com Pontes
/
Espectrometria de Massas por Ionização por Electrospray
Limite:
Animais
Idioma:
Chinês
Revista:
Acta Pharmaceutica Sinica
Ano de publicação:
2010
Tipo de documento:
Artigo