Expression of nuclear factor-kappaB in bone marrow cells from patients with acute leukemia and its relationship with P21, MMP-2 and MMP-9 / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 243-245, 2003.
Article
em Zh
| WPRIM
| ID: wpr-355673
Biblioteca responsável:
WPRO
ABSTRACT
To investigate the expression of NF-kappaB in acute leukemia and its relationship with P21, and matrix metalloproteinases (MMP), the expression of NF-kappaB, P21, MMP-2 and MMP-9 in bone marrow cells from patients with acute leukemia (AL) was detected using immunocytochemical technique. The results showed that the expression ratios of NF-kappaB, P21, MMP-2 and MMP-9 in untreated AL group were significantly higher than those in remission and normal control groups (P < 0.05), and no obvious difference was seen between remission and normal control groups. The expression of NF-kappaB was correlated with that of P21, MMP-2 and MMP-9 (r = 0.767, 0.729 and 0.803, respectively, P < 0.05). This study indicated that P21 protein, encoded by oncogene Ras, and NF-kappaB were super-expressed in leukemia cells. In conclusion, after activation by Ras, NF-kappaB combined with the kappaB sequences of MMP-2 and MMP-9 genes, then upregulated their expression. MMP might enhance the degradative function of leukemic cell, thus to make cells easier to cross through the bone marrow barrier and release into blood.
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Patologia
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Indução de Remissão
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Células da Medula Óssea
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Imuno-Histoquímica
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Leucemia
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Doença Aguda
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NF-kappa B
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Proteínas Proto-Oncogênicas p21(ras)
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Metaloproteinase 2 da Matriz
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Metaloproteinase 9 da Matriz
Limite:
Adult
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Ano de publicação:
2003
Tipo de documento:
Article